Persistent Detrusor Overactivity in Rats after 4 Relief of Partial Urethral Obstruction
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چکیده
1 2 3 Persistent Detrusor Overactivity in Rats after 4 Relief of Partial Urethral Obstruction 5 6 Long-Hu Jin, Karl-Erik Andersson, Jeong-Uk Han, Yong-Hyun Kwon, Chang-Shin 7 Park, Hwa-Yoan Shin, Sang-Min Yoon, Tack Lee 8 Departments of Urology, Anesthesiology and Pharmacology, Inha University College 9 of Medicine by BK 21 project, Incheon, Korea; and Wake Forest Institute for 10 Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, 11 NC, USA 12 13 14 Corresponding author. : Tack Lee, M.D., Ph.D. 15 Department of Urology, 16 Inha University College of Medicine by BK 21 project, 17 Jung-Suk Build. 5 Floor, 7-241, 18 3-Ga, Shinheung-Dong, Jung-Gu, Incheon, 400-711, South Korea 19 Phone: +82-32-890-3448 20 Fax: +82-32-890-3097 21 E-mail address: [email protected] 22 Word Count: 4179 23
منابع مشابه
Persistent detrusor overactivity in rats after relief of partial urethral obstruction.
Detrusor overactivity (DO) persists after prostatectomy in 20% to 25% of patients with benign disease. Assuming that nonvoiding contractions (NVCs) can be used as a surrogate for DO in humans, the rat model of obstruction/deobstruction may allow us to study the pathophysiology of persistent DO after deobstruction. We investigated bladder function, with a special focus on NVCs, in rats by use of...
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PURPOSE This study was designed to investigate the effect of detrusor overactivity induced by partial bladder outlet obstruction (BOO) on the expression of aquaporin 1 (AQP1) and caveolin 1 (CAV1) in the rat urinary bladder, and to determine the role of these molecules in detrusor overactivity. METHODS Female Sprague-Dawley rats were divided into control (n=30) and experimental (n=30) groups....
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To evaluate the changes in intercellular communication through gap junctions in detrusor overactivity (DO), we studied 23 adult female Wistar rats with DO after partial outflow obstruction (DO group) and 13 sham-operated rats (control group). The two groups were compared by means of urodynamics, light and electron microscopy, expression of Cx40, Cx43, and Cx45 mRNA genes with RT-PCR, Cx43 prote...
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